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Dermatology

Psoriasis

What is psoriasis?

Psoriasis is a chronic inflammatory skin condition characterised by clearly defined, red and scaly plaques (thickened skin). It is classified into several subtypes.

 

Who gets psoriasis?

Psoriasis affects 2–4% of males and females. It can start at any age including   childhood, with peaks of onset at 15–25 years and 50–60 years. It tends to persist lifelong, fluctuating in extent and severity. It is particularly common in Caucasians, but may affect people of any race. About one third of patients with psoriasis have family members with psoriasis.

 

What causes psoriasis?

Psoriasis is multifactorial. It is classified as an immune-mediated inflammatory disease (IMID).

Genetic factors are important. An individual's genetic profile influences their type of psoriasis and its response to treatment.

Genome-wide association studies report that HLA-Cw6 is associated with early onset psoriasis and guttate psoriasis. This major histocompatibility complex is not associated with arthritis, nail dystrophy or late onset psoriasis.

Theories about the causes of psoriasis need to explain why the skin is red, inflamed and thickened. It is clear that immune factors and inflammatory cytokines (messenger proteins) such is IL1β and TNFα are responsible for the clinical features of psoriasis. Current theories are exploring the TH17 pathway and release of the cytokine IL17A.

 

What are the clinical features of psoriasis?

Psoriasis usually presents with symmetrically distributed, red, scaly plaques with well-defined edges. The scale is typically silvery white, except in skin folds where the plaques often appear shiny and they may have a moist peeling surface. The most common sites are scalp, elbows and knees, but any part of the skin can be involved. The plaques are usually very persistent without treatment.

Itch is mostly mild but may be severe in some patients, leading to scratching and lichenification (thickened leathery skin with increased skin markings). Painful skin cracks or fissures may occur.

When psoriatic plaques clear up, they may leave brown or pale marks that can be expected to fade over several months.

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Ailesbury Dublin
David Lloyd Riverview,

1st Floor,
Beech Hill Road,
Donnybrook  Dublin 4.

Tel:   (01)269 2255 / 2133

Email:reception@ailesburyclinic.ie

Fax: (01) 218 0857

 

 

 

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Ailesbury Cork

Holbar House
East Village
Douglas, Cork.

Tel: (01) 269 2255 

Cork (021) 4835006

Email:reception@ailesburyclinic.ie    

Fax: (01) 218 0857

 

 

 

 

 

 

 

 

 

 

patrick treacy

AMEC AWARDS 2014 & 2016

Ailesbury Clinics are the only clinic in the world to have won two AMEC Awards and ' Best Medical Research in Ireland 2017'. Specialists in Dermatology and Aesthetic Medicine. We perform minor surgery + skin cancer screen. VHI, Aviva, Laya and Irish Health accepted. Hstopathology performed at St. Vincent's University Hospital, Dublin. Consultation €120  READ MORE Please read all of our Ailesbury Clinic BLOGS

 

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