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Platelet-rich plasma in Aesthetic Medicine

Platelet-rich plasma (Abbreviation: PRP) is blood plasma that has been enriched with platelets. As a concentrated source of autologous platelets, PRP contains (and releases through degranulation) several different growth factors and other cytokines that stimulate healing of bone and soft tissue. The efficacy of certain growth factors in healing various injuries and the concentrations of these growth factors found within PRP are the theoretical basis for the use of PRP in tissue repair. The platelets collected in PRP are SOMETIMES activated by the addition of thrombin and calcium chloride, which induces the release of these factors from alpha granules. The growth factors and other cytokines present in PRP include: Platelet-rich plasma (PRP) is an orthobiologic that has recently gained popularity as an adjuvant treatment for ANTI-AGEING. It is a volume of fractionated plasma from the patient's own blood that contains platelet concentrate. The platelets contain alpha granules that are rich in several growth factors, such as platelet-derived growth factor, transforming growth factor-β, insulin-like growth factor, vascular endothelial growth factor and epidermal growth factor, which play key roles in tissue repair mechanisms

    • platelet-derived growth factor

    • transforming growth factor beta

    • fibroblast growth factor

    • insulin-like growth factor 1

    • insulin-like growth factor 2

    • vascular endothelial growth factor

    • epidermal growth factor

    • Interleukin 8

    • keratinocyte growth factor

    • connective tissue growth factor 

       RTE Television interviews Dr. Patrick Treacy about PRP (Vampire Facelift). Maia Dunphy from RTE Television prodcuer of 'What Women Want' interviews Dr. Patrick Treacy about PRP (Vampire Facelift) at Ailesbury Clinic Dublin and selects a patient for the treatment 

    • Activation of PRP before injecting  When PRP is activated ex vivo before injecting, usually by adding calcium chloride or calcium gluconate, there is an immediate release of growth factors. This also causes a thickening of the PRP to form a higher viscosity gel or even a clot.   Injecting needs to take place promptly.

    • Non-activation of PRP before injecting It is believed that growth factors should be released by platelets in situ at the optimum time. that the releasing of growth factors ex vivo before injecting reduces the PRP effectiveness compared with secreting of growth factors in vivo from the natural action of thrombin and/or collagen of the patient. Growth factors released as the platelets are optimally ruptured in situ, are more effective.

    • Activation of Cellenis PRP occurs as follows: 1) Mechanical activation begins when inactivated PRP is injected via needle  2) Activation continues during injecting when PRP meets with the patient’s blood which contains thrombin 3) Activation further continues when PRP meets collagen in the endothelial cell walls and ECM. If Cellenis PRP users ever do prefer to microactivate before injecting to start the activation process, this certainly can be done.   Simply add a 20% CaCl2 solution in a ratio of 10:1   Cellenis will still be liquid enough to inject but micro-activation will begin (Advice from Roseanne Aitken-Cellenis) 

    • Combination of PRP with other means of treatment 
    • Combination with HLA- Hyaluronic Acid many clinicians use a 1:1 ratio. This can be mixed before hand or injected separately 

    •  Lecture given by Dr. Patrick Treacy about PRP in combination therapy. Keynote speaker AAAM Mexico 2013
    • Combination of PRP with LLLT and CIT (microneedling) 
    • The Dublin lift is an award-winning multiprocedural approach to volumisation and collagen regeneration by Dr. Patrick Treacy. The procedures evaluated included platelet rich plasma (PRP), microneedling (MN), Omnilux 633nm near-red light (LLLT) with neurotoxins as an adjunct to low level FLRS. Cells in the epidermis and dermis were targeted by (MN) and near-red light (633nm) resulting in fibroblast stimulation. The degree of perceived improvement in overall aesthetic effect reflecting chronological age was assessed separately by patients and physicians using the Wrinkle Severity Rating Scale and the Global Aesthetic Improvement Scale. The technique is called the DUBLiN facelift as an acronym of the procedures involved. D Dermaroller U Ultralase Laser B Blood growth factors Li Light (near red 633) N Neurotoxin.
    •  

    • Lecture given by Dr. Patrick Treacy about PRP in combination therapy. Keynote speaker IMCAS China 2015 
    • PRP injection for androgenic alopecia

    • Platelet-rich plasma (PRP) has become a newer method for the treatment of various types of alopecia. PRP injection for androgenic alopecia is a simple, cost-effective and feasible treatment option for hair loss and can be regarded as a valuable adjuvant treatment modality for androgenic alopecia. Although PRP has sufficient theoretical scientific basis to support its use in hair restoration, hair restoration using PRP is still at its infancy. Clinical evidence is still weak. Considering its excellent safety profile and relatively low cost, PRP hair treatment is a promising treatment option for patients with thinning hair.
    • Hair loss has a significant influence on psychological distress and is associated with low self-esteem and depression. Treatment options for androgenic alopecia are very limited and include topical minoxidil and oral finasteride (FDA approved) either alone or in combination (1) Uebel et al. observed a significant improvement in hair density and stimulation of growth when follicular units were pre-treated with platelet plasma growth factors before their implantation. There was a significant difference in the yield of follicular units on comparing the experimental with the control areas of the scalp (2). 

  • The PRP-SHOT (Platelet Rich Plasma) for sexual rejuvenation and enhancement.
  • This treatment is all about giving women and men more confidence and restoring sexual function. The PRP-SHOT is a treatment that uses your body’s own platelets, cells that form new tissues, to apparently rejuvenate your erogenous areas and sexual function. It claims to increase sexual desire and enhance your sexual experience and feeling.

    The PRP-SHOT treats female sexual disorder (difficulty getting aroused), female orgasmic disorder (difficulty climaxing) and hypoactive sexual desire (low desire). It has also alleged to be effective in treating physical conditions such as urinary incontinence and dyspareunia (pain during sex), both of which can be caused by child birth, menopause, or can also arise as part of the natural ageing process. The PRP-SHOT  also claims to treat male erectile dysfunction, giving increases in size and hardness. It also treats Peyronies disease (shape disorders leading to pain) and improves sensation for clients after a prostatectomy.

  • (1) Topical minoxidil in early male pattern baldness.Olsen EA, Weiner MS, Delong ER, Pinnell SRJ Am Acad Dermatol. 1985 Aug; 13(2 Pt 1):185-92.
  • (2) Platelet-Rich Plasma in Androgenic Alopecia: Myth or an Effective Tool
    Swapna S Khatu, Yuvraj E More, Neeta R Gokhale, Dipali C Chavhan, and Nitin Bendsure

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patrick treacy

AMEC AWARDS 2014 & 2016

Ailesbury Clinics are the only clinic in the world to have won two AMEC Awards and ' Best Medical Research in Ireland 2017'. Specialists in Dermatology and Aesthetic Medicine. We perform minor surgery + skin cancer screen. VHI, Aviva, Laya and Irish Health accepted. Hstopathology performed at St. Vincent's University Hospital, Dublin. Consultation €120  READ MORE Please read all of our Ailesbury Clinic BLOGS

 

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