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Skin Cancer Updates

Melanoma: Pembrolizumab

Pembrolizumab (Keytruda) provided promising antitumor activity in Japanese patients with advanced melanoma and a safety profile similar to that reported in other studies.Why this matters

  • These early data support further clinical development for the use of pembrolizumab in this population.

Study design

  • A phase Ib study that evaluated the safety and antitumor activity of pembrolizumab in 42 Japanese patients with advanced melanoma (37 evaluable).
  • Funding: MSD K.K.

Key results

  • 75.7% (n=28) of the cohort had tumor shrinkage of varying degrees.
  • Overall response rate (ORR) was 24.1% for the 29 patients with cutaneous melanoma.
  • Median time to response was 12.3 wk, and median duration was not reached.
  • Of 7 patients who experienced a response, 5 (71.4%) have stayed progression-free.
  • Median PFS for the cutaneous melanoma cohort was 4.2 mo.
  • Of the 8 patients with mucosal melanoma, the ORR was 25.0% (n=2), and median time to response was 17.8 wk. Median duration has not yet been reached, and the 2 patients who responded remain progression-free.
  • Median PFS for the mucosal melanoma cohort was 3.4 mo.
  • 81.0% experienced at least 1 adverse event.

Limitations

  • Early-phase data.

 

Yamazaki N, Takenouchi T, Fujimoto M, Ihn H, Uchi H, Inozume T, Kiyohara Y, Uhara H, Nakagawa K, Furukawa H, Wada H, Noguchi K, Shimamoto T, Yokota K. Phase 1b study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced melanoma (KEYNOTE-041). Cancer Chemother Pharmacol. 2017 Mar 11 [Epub ahead of print]. doi: 10.1007/s00280-016-3237-x. PMID: 28283736

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Tel:   (01)269 2255 / 2133

Email:reception@ailesburyclinic.ie

Fax: (01) 218 0857 

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Ailesbury Cork

Holbar House  

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Email:reception@ailesburyclinic.ie

Fax: (01) 218 0857

 

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Congratulations to our own Ailesbury Doctor Dr Olga O' Driscoll coming 1st out of 100 doctors in the St. Mary's Diploma in Aesthetic Medicine and securing a mentorship under Dr. Adriano Santorelli in Naples.

 

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Galway (091)568 555

Email:reception@ailesburyclinic.ie

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Specialists in Dermatology and Aesthetic Medicine. We perform minor surgery + skin cancer screen. VHI, Aviva, Laya and Irish Health accepted. Hstopathology is covered by private insurance and performed by dedicated skin histopathologists at St. Vincent's University Hospital, Dublin. Consultation €100  READ MORE 

 

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