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Ailesbury Clinic Blog

Melanoma: higher vitamin D levels may indicate better prognosis


  • Higher levels of vitamin D are associated with better prognosis in melanoma.

Why this matters

  • The study found an association with prognostic indicators, but a causative relationship cannot be confirmed.

Study design

  • Retrospective pilot study evaluating the association between the clinicopathological features of melanoma and corresponding serum vitamin D level in the patient; cohort was comprised of 109 melanomas diagnosed at a single center.
  • Funding: None disclosed.

Key results

  • Vitamin deficiency was identified in 32% of patients (vitamin D level <50 nmol/L).
  • Breslow thickness was associated with vitamin D level; higher mean serum vitamin D levels were noted in the thin tumors (mean, 67.0 nmol/L) compared with thick tumors (mean, 57.6 nmol/L; P=.045).
  • After controlling for age and sex, higher serum vitamin D was significantly associated with lower Breslow thickness (r2, 0.055; test for linear trend P=.026).
  • Mean serum vitamin D levels were higher in nonulcerated lesions (mean, 64.6 nmol/L) vs ulcerated ones (mean, 47.27 nmol/L; P=.006).
  • Vitamin D levels were highest in melanoma desmoplastic melanoma subtypes (mean, 79.3 nmol/L) and superficial spreading melanoma (67.4 nmol/L; P=.019).


  • Vitamin D levels not compared with those of healthy control patients.

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