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Skin Cancer Updates

Melanoma: Vitamin D levels


  • Higher levels of vitamin D are associated with better prognosis in melanoma.

Why this matters

  • The study found an association with prognostic indicators, but a causative relationship cannot be confirmed.

Study design

  • Retrospective pilot study evaluating the association between the clinicopathological features of melanoma and corresponding serum vitamin D level in the patient; cohort was comprised of 109 melanomas diagnosed at a single center.
  • Funding: None disclosed.

Key results

  • Vitamin deficiency was identified in 32% of patients (vitamin D level
  • Breslow thickness was associated with vitamin D level; higher mean serum vitamin D levels were noted in the thin tumors (mean, 67.0 nmol/L) compared with thick tumors (mean, 57.6 nmol/L; P=.045).
  • After controlling for age and sex, higher serum vitamin D was significantly associated with lower Breslow thickness (r2, 0.055; test for linear trend P=.026).
  • Mean serum vitamin D levels were higher in nonulcerated lesions (mean, 64.6 nmol/L) vs ulcerated ones (mean, 47.27 nmol/L; P=.006).
  • Vitamin D levels were highest in melanoma desmoplastic melanoma subtypes (mean, 79.3 nmol/L) and superficial spreading melanoma (67.4 nmol/L; P=.019).


  • Vitamin D levels not compared with those of healthy control patients.

Ailesbury Dublin

David Lloyd Riverview,

1st Floor,

Beech Hill Road,
Donnybrook  Dublin 4.

Eircode DO4 AF10 (Google Map)

Tel:   (01)269 2255 / 2133

Fax: (01) 218 0857 

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Ailesbury Cork

Holbar House  

East Village Medical Cntre

Douglas, Cork 

Eircode T12 HK2C (Google Map)

Tel:   (021) 4835006


Fax: (01) 218 0857


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